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Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology?

Cartwright, JE; Whitley, GS (2017) Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology? Placenta, 60. pp. 145-149. ISSN 1532-3102 https://doi.org/10.1016/j.placenta.2017.05.003
SGUL Authors: Cartwright, Judith Eleanor Whitley, Guy St John

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Abstract

The pathologies of the pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy. In a normal pregnancy, decidual spiral arteries are transformed into wide diameter, non-vasoactive vessels capable of meeting the increased demands of the developing fetus for nutrients and oxygen. Disruption of this transformation is associated with PE and FGR. Very little is known of how these first trimester changes are regulated normally and even less is known about how they are compromised in complicated pregnancies. Interactions between maternal and placental cells are essential for pregnancy to progress and this review will summarise the challenges in investigating this area. We will discuss how first trimester studies of pregnancies with an increased risk of developing PE/FGR have started to provide valuable information about pregnancy at this most dynamic and crucial time. We will discuss where there is scope to progress these studies further by refining the ability to identify compromised pregnancies at an early stage, by integrating information from many cell types from the same pregnancy, and by improving our methods for modelling the maternal-fetal interface in vitro.

Item Type: Article
Additional Information: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Decidua, First trimester, Placenta, Pre-eclampsia, Uterine artery doppler screening, Decidua, First trimester, Placenta, Pre-eclampsia, Uterine artery doppler screening, Obstetrics & Reproductive Medicine, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular (INCCVA)
Journal or Publication Title: Placenta
ISSN: 1532-3102
Language: eng
Dates:
DateEvent
December 2017Published
6 May 2017Published Online
5 May 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDBill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865
0191550Wellcome Trusthttp://dx.doi.org/10.13039/100004440
SP4577Action Medical Researchhttp://dx.doi.org/10.13039/501100000317
MR/M02184X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 28506493
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108877
Publisher's version: https://doi.org/10.1016/j.placenta.2017.05.003

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