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Maternal vaccination against pertussis: a systematic review of the recent literature

Gkentzi, D; Katsakiori, P; Marangos, M; Hsia, Y; Amirthalingam, G; Heath, PT; Ladhani, S (2017) Maternal vaccination against pertussis: a systematic review of the recent literature. Archives of Disease in Childhood, 102 (5). F456-F463. ISSN 1468-2044 https://doi.org/10.1136/archdischild-2016-312341
SGUL Authors: Heath, Paul Trafford Ladhani, Shamez Nizarali Hsia, Yingfen

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Abstract

Objective This study is conducted to summarise and present the current knowledge on antenatal vaccination against pertussis with regard to national recommendations, coverage, immunogenicity, safety and effectiveness of the current available vaccines. Methods A systematic review of the literature in English was undertaken from January 2011 to May 2016 with searches in four databases. The review conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results 47 studies fulfilled the inclusion criteria. Antenatal vaccination against pertussis induces high antibody concentrations in pregnant women, which are efficiently transferred transplacentally to the fetus and protect newborns when they are most vulnerable to pertussis. This strategy has been demonstrated to be safe, with no evidence of adverse pregnancy, birth or neonatal outcomes. Several countries have already introduced antenatal pertussis vaccination into their national immunisation programme with varying vaccination coverage influenced by various factors. Barriers to achieving high immunisation rates could be improved through better education of the public and healthcare professionals. Conclusions There is now an increasing body of evidence to support the safety, immunogenicity and effectiveness of antenatal vaccination to reduce the morbidity and mortality associated with pertussis in neonates and young infants before they receive their primary immunisations. Narrowing the gap between scientific evidence and public health policies is critical in order to protect the most vulnerable as quickly as possible. The lessons learnt have important implications for implementation of new vaccines into the antenatal immunisation programme.

Item Type: Article
Additional Information: This article has been accepted for publication in Archives of Disease in Childhood following peer review. The definitive copyedited, typeset version Gkentzi D, Katsakiori P, Marangos M, et al Maternal vaccination against pertussis: a systematic review of the recent literature Archives of Disease in Childhood - Fetal and Neonatal Edition 2017;102:F456-F463 is available online at: http://doi.org/10.1136/archdischild-2016-312341
Keywords: Pediatrics, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Archives of Disease in Childhood
ISSN: 1468-2044
Dates:
DateEvent
1 September 2017Published
3 May 2017Published Online
3 April 2017Accepted
Publisher License: Publisher's own licence
URI: http://openaccess.sgul.ac.uk/id/eprint/108835
Publisher's version: https://doi.org/10.1136/archdischild-2016-312341

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