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Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks.

Herz, DM; Tan, H; Brittain, J-S; Fischer, P; Cheeran, B; Green, AL; FitzGerald, J; Aziz, TZ; Ashkan, K; Little, S; et al. Herz, DM; Tan, H; Brittain, J-S; Fischer, P; Cheeran, B; Green, AL; FitzGerald, J; Aziz, TZ; Ashkan, K; Little, S; Foltynie, T; Limousin, P; Zrinzo, L; Bogacz, R; Brown, P (2017) Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks. Elife, 6. e21481. ISSN 2050-084X https://doi.org/10.7554/eLife.21481
SGUL Authors: Cheeran, Binith

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Abstract

Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and electroencephalography in 11 Parkinson's disease patients during a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2-8 Hz), coupled to activity at prefrontal electrode Fz, and STN beta activity (13-30 Hz) coupled to electrodes C3/C4 close to motor cortex. These two correlates differed not only in their cortical topography and spectral characteristics but also in the relative timing of recruitment and in their precise relationship with decision thresholds. Increases of STN LFO power preceding the response predicted increased thresholds only after accuracy instructions, while cue-induced reductions of STN beta power decreased thresholds irrespective of instructions. These findings indicate that distinct neural mechanisms determine whether a decision will be made in haste or with caution.

Item Type: Article
Additional Information: Copyright Herz et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: decision thresholds, human, neuroscience, speed-accuracy tradeoff, subthalamic nucleus
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Elife
ISSN: 2050-084X
Language: eng
Dates:
DateEvent
31 January 2017Published
15 January 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
MC_UU_12024/1Medical Research CouncilUNSPECIFIED
MC_UU_12024/5Medical Research CouncilUNSPECIFIED
PubMed ID: 28137358
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108793
Publisher's version: https://doi.org/10.7554/eLife.21481

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