SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Placental transfer of antibody and its relationship to vaccination in pregnancy.

Calvert, A; Jones, CE (2017) Placental transfer of antibody and its relationship to vaccination in pregnancy. Curr Opin Infect Dis, 30 (3). pp. 268-273. ISSN 1473-6527 https://doi.org/10.1097/QCO.0000000000000372
SGUL Authors: Jones, Christine Elizabeth Calvert, Anna Louise

[img] Microsoft Word (.docx) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (40kB)

Abstract

PURPOSE OF REVIEW: Vaccination in pregnancy boosts maternal vaccine-specific antibody concentration and therefore increases transplacental transfer of antibody to optimize protection of the infant. The purpose of this review is to describe what is known about placental transfer of antibody in the context of vaccination in pregnancy, focussing on the recent literature and areas of debate, particularly about the timing of vaccination. RECENT FINDINGS: There is a debate about the timing of pertussis vaccination in pregnancy with some studies reporting that vaccination in the third trimester results in higher pertussis antigen-specific IgG concentrations in cord blood and others finding that the concentration is higher following vaccination in the second trimester. The impact of timing of vaccination on antibody avidity in cord blood has also been investigated and one study suggests that avidity may be increased following vaccination at 27-30 gestational weeks compared with later vaccination. SUMMARY: Understanding placental transfer of antibody is vital in informing maternal vaccination strategy. There has been recent research about the timing of pertussis vaccination in pregnancy that has implications for the timing of both current and future vaccines to be used in pregnancy.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Calvert, A; Jones, CE (2017) Placental transfer of antibody and its relationship to vaccination in pregnancy. Curr Opin Infect Dis, 30 (3). pp. 268-273
Keywords: 1103 Clinical Sciences, 1108 Medical Microbiology, 0605 Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Curr Opin Infect Dis
ISSN: 1473-6527
Language: eng
Dates:
DateEvent
June 2017Published
30 March 2017Published Online
13 March 2017Accepted
Publisher License: Publisher's own licence
PubMed ID: 28362650
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108750
Publisher's version: https://doi.org/10.1097/QCO.0000000000000372

Actions (login required)

Edit Item Edit Item