SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Hepatitis C virus infection, and neurological and psychiatric disorders - A review.

Yarlott, L; Heald, E; Forton, D (2017) Hepatitis C virus infection, and neurological and psychiatric disorders - A review. J Adv Res, 8 (2). pp. 139-148. ISSN 2090-1232 https://doi.org/10.1016/j.jare.2016.09.005
SGUL Authors: Forton, Daniel Michael

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (601kB) | Preview

Abstract

An association between hepatitis C virus infection and neuropsychiatric symptoms has been proposed for some years. A variety of studies have been undertaken to assess the nature and severity of these symptoms, which range from fatigue and depression to defects in attention and verbal reasoning. There is evidence of mild neurocognitive impairment in some patients with HCV infection, which is not fully attributable to liver dysfunction or psychosocial factors. Further evidence of a biological cerebral effect has arisen from studies using magnetic resonance spectroscopy; metabolic abnormalities correlate with cognitive dysfunction and resemble the patterns of neuroinflammation that have been described in HIV infection. Recent research has suggested that, in common with HIV infection, HCV may cross the blood brain barrier leading to neuroinflammation. Brain microvascular endothelial cells, astrocytes and microglia may be minor replication sites for HCV. Importantly, patient reported outcomes improve following successful antiviral therapy. Further research is required to elucidate the molecular basis for HCV entry and replication in the brain, and to clarify implications and recommendations for treatment.

Item Type: Article
Additional Information: © 2016 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Brain, Cognitive, Cytokine, Hepatitis C, Quasispecies
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: J Adv Res
ISSN: 2090-1232
Language: eng
Dates:
DateEvent
March 2017Published
19 September 2016Published Online
9 September 2016Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 28149649
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108743
Publisher's version: https://doi.org/10.1016/j.jare.2016.09.005

Actions (login required)

Edit Item Edit Item