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Assessment of Pediatric asthma drug use in three European countries; a TEDDY study

Sen, EF; Verhamme, KMC; Neubert, A; Hsia, Y; Murray, M; Felisi, M; Giaquinto, C; ‘t Jong, GW; Picelli, G; Baraldi, E; et al. Sen, EF; Verhamme, KMC; Neubert, A; Hsia, Y; Murray, M; Felisi, M; Giaquinto, C; ‘t Jong, GW; Picelli, G; Baraldi, E; Nicolosi, A; Ceci, A; Wong, IC; Sturkenboom, MCJM (2011) Assessment of Pediatric asthma drug use in three European countries; a TEDDY study. European Journal of Pediatrics, 170 (1). pp. 81-92. ISSN 0340-6199 https://doi.org/10.1007/s00431-010-1275-7
SGUL Authors: Hsia, Yingfen

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Abstract

Asthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands (NL), Italy (IT), and the United Kingdom (UK). We conducted a retrospective analysis of outpatient medical records of children 0–18 years from 1 January 2000 until 31 December 2005. For all children, prescription rates of asthma drugs were studied by country, age, asthma diagnosis, and off-label status. One-year prevalence rates were calculated per 100 children per patient-year (PY). The cohort consisted of 671,831 children of whom 49,442 had been diagnosed with asthma at any time during follow-up. ß2-mimetics and inhaled steroids were the most frequently prescribed asthma drug classes in NL (4.9 and 4.1/100 PY), the UK (8.7 and 5.3/100 PY) and IT (7.2 and 16.2/100 PY), respectively. Xanthines, anticholinergics, leukotriene receptor antagonists, and anti-allergics were prescribed in less than one child per 100 per year. In patients without asthma, ß2-mimetics were used most frequently. Country differences were highest for steroids, (Italy highest), and for ß2-mimetics (the UK highest). Off-label use was low, and most pronounced for ß2-mimetics in children <18 months (IT) and combined ß2-mimetics + anticholinergics in children <6 years (NL). Conclusion: This study shows that among all asthma drugs, ß2-mimetics and inhaled steroids are most often used, also in children without asthma, and with large variability between countries. Linking multi-country databases allows us to study country specific pediatric drug use in a systematic manner without being hampered by methodological differences. This study underlines the potency of healthcare databases in rapidly providing data on pediatric drug use and possibly safety.

Item Type: Article
Additional Information: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Keywords: Pediatrics, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: European Journal of Pediatrics
ISSN: 0340-6199
Dates:
DateEvent
2 September 2010Published Online
January 2011Published
10 August 2010Accepted
Publisher License: Creative Commons: Attribution-Noncommercial 4.0
URI: http://openaccess.sgul.ac.uk/id/eprint/108701
Publisher's version: https://doi.org/10.1007/s00431-010-1275-7

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