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Promiscuity among the MRAPs.

Clark, AJL; Chan, LF (2017) Promiscuity among the MRAPs. J Mol Endocrinol, 58. F1-F4. ISSN 1479-6813 https://doi.org/10.1530/JME-17-0002
SGUL Authors: Clark, Adrian John L

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Abstract

The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ligand binding. A related molecule, MRAP2, is mainly expressed in the CNS and appears to have a role with the melanocortin 4 receptor. Consistent with this is the observation that a massively obese phenotype develops when the Mrap2 gene is deleted in mice. However, the characteristics of this phenotype differ from those of Mc4r deleted mice, and suggest that an additional role, possibly resulting from an interaction with other receptors is possible. In support of this, a functional interaction with the prokineticin receptors was recently reported. Evidence for other receptor interactions and aspects of the tissue distribution of MRAP and MRAP2 gene expression may indicate that these accessory proteins have a wider role than with the melanocortin receptors alone.

Item Type: Article
Additional Information: Disclaimer: this is not the definitive version of record of this article.This manuscript has been accepted for publication in Journal of Molecular Endocrinology, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at http://dx.doi.org/10.1530/JME-17-0002 2017.
Keywords: Endocrinology & Metabolism, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine, 0707 Veterinary Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Mol Endocrinol
ISSN: 1479-6813
Language: eng
Dates:
DateEvent
1 April 2017Published
17 February 2017Published Online
17 February 2017Accepted
Publisher License: Publisher's own licence
PubMed ID: 28213370
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108651
Publisher's version: https://doi.org/10.1530/JME-17-0002

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