Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Surgical Neurostimulation for Spinal Cord Injury.

Chari, A; Hentall, ID; Papadopoulos, MC; Pereira, EAC (2017) Surgical Neurostimulation for Spinal Cord Injury. Brain Sci, 7 (2). p. 18. ISSN 2076-3425
SGUL Authors: Papadopoulos, Marios Pereira, Erlick Abilio Coelho

PDF Published Version
Available under License Creative Commons Attribution.

Download (563kB) | Preview


Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI.

Item Type: Article
Additional Information: © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Keywords: deep brain stimulation, neuromodulation, spinal cord injury, spinal cord stimulation
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Brain Sci
ISSN: 2076-3425
Language: eng
10 February 2017Published
2 February 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 28208601
Go to PubMed abstract
Publisher's version:


Item downloaded times since 02 Mar 2017.

Actions (login required)

Edit Item Edit Item