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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D; et al. Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D; Ngwa, JS; Ahluwalia, TS; Chu, AY; Heard-Costa, NL; Lim, E; Perez, J; Eicher, JD; Kutalik, Z; Xue, L; Mahajan, A; Renström, F; Wu, J; Qi, Q; Ahmad, S; Alfred, T; Amin, N; Bielak, LF; Bonnefond, A; Bragg, J; Cadby, G; Chittani, M; Coggeshall, S; Corre, T; Direk, N; Eriksson, J; Fischer, K; Gorski, M; Neergaard Harder, M; Horikoshi, M; Huang, T; Huffman, JE; Jackson, AU; Justesen, JM; Kanoni, S; Kinnunen, L; Kleber, ME; Komulainen, P; Kumari, M; Lim, U; Luan, J; Lyytikäinen, L-P; Mangino, M; Manichaikul, A; Marten, J; Middelberg, RPS; Müller-Nurasyid, M; Navarro, P; Pérusse, L; Pervjakova, N; Sarti, C; Smith, AV; Smith, JA; Stančáková, A; Strawbridge, RJ; Stringham, HM; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van der Most, PJ; Van Vliet-Ostaptchouk, JV; Vedantam, SL; Verweij, N; Vink, JM; Vitart, V; Wu, Y; Yengo, L; Zhang, W; Hua Zhao, J; Zimmermann, ME; Zubair, N; Abecasis, GR; Adair, LS; Afaq, S; Afzal, U; Bakker, SJL; Bartz, TM; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boerwinkle, E; Bonnycastle, LL; Bottinger, E; Braga, D; Buckley, BM; Buyske, S; Campbell, H; Chambers, JC; Collins, FS; Curran, JE; de Borst, GJ; de Craen, AJM; de Geus, EJC; Dedoussis, G; Delgado, GE; den Ruijter, HM; Eiriksdottir, G; Eriksson, AL; Esko, T; Faul, JD; Ford, I; Forrester, T; Gertow, K; Gigante, B; Glorioso, N; Gong, J; Grallert, H; Grammer, TB; Grarup, N; Haitjema, S; Hallmans, G; Hamsten, A; Hansen, T; Harris, TB; Hartman, CA; Hassinen, M; Hastie, ND; Heath, AC; Hernandez, D; Hindorff, L; Hocking, LJ; Hollensted, M; Holmen, OL; Homuth, G; Jan Hottenga, J; Huang, J; Hung, J; Hutri-Kähönen, N; Ingelsson, E; James, AL; Jansson, J-O; Jarvelin, M-R; Jhun, MA; Jørgensen, ME; Juonala, M; Kähönen, M; Karlsson, M; Koistinen, HA; Kolcic, I; Kolovou, G; Kooperberg, C; Krämer, BK; Kuusisto, J; Kvaløy, K; Lakka, TA; Langenberg, C; Launer, LJ; Leander, K; Lee, NR; Lind, L; Lindgren, CM; Linneberg, A; Lobbens, S; Loh, M; Lorentzon, M; Luben, R; Lubke, G; Ludolph-Donislawski, A; Lupoli, S; Madden, PAF; Männikkö, R; Marques-Vidal, P; Martin, NG; McKenzie, CA; McKnight, B; Mellström, D; Menni, C; Montgomery, GW; Musk, AB; Narisu, N; Nauck, M; Nolte, IM; Oldehinkel, AJ; Olden, M; Ong, KK; Padmanabhan, S; Peyser, PA; Pisinger, C; Porteous, DJ; Raitakari, OT; Rankinen, T; Rao, DC; Rasmussen-Torvik, LJ; Rawal, R; Rice, T; Ridker, PM; Rose, LM; Bien, SA; Rudan, I; Sanna, S; Sarzynski, MA; Sattar, N; Savonen, K; Schlessinger, D; Scholtens, S; Schurmann, C; Scott, RA; Sennblad, B; Siemelink, MA; Silbernagel, G; Slagboom, PE; Snieder, H; Staessen, JA; Stott, DJ; Swertz, MA; Swift, AJ; Taylor, KD; Tayo, BO; Thorand, B; Thuillier, D; Tuomilehto, J; Uitterlinden, AG; Vandenput, L; Vohl, M-C; Völzke, H; Vonk, JM; Waeber, G; Waldenberger, M; Westendorp, RGJ; Wild, S; Willemsen, G; Wolffenbuttel, BHR; Wong, A; Wright, AF; Zhao, W; Zillikens, MC; Baldassarre, D; Balkau, B; Bandinelli, S; Böger, CA; Boomsma, DI; Bouchard, C; Bruinenberg, M; Chasman, DI; Chen, Y-D; Chines, PS; Cooper, RS; Cucca, F; Cusi, D; Faire, UD; Ferrucci, L; Franks, PW; Froguel, P; Gordon-Larsen, P; Grabe, H-J; Gudnason, V; Haiman, CA; Hayward, C; Hveem, K; Johnson, AD; Wouter Jukema, J; Kardia, SLR; Kivimaki, M; Kooner, JS; Kuh, D; Laakso, M; Lehtimäki, T; Marchand, LL; März, W; McCarthy, MI; Metspalu, A; Morris, AP; Ohlsson, C; Palmer, LJ; Pasterkamp, G; Pedersen, O; Peters, A; Peters, U; Polasek, O; Psaty, BM; Qi, L; Rauramaa, R; Smith, BH; Sørensen, TIA; Strauch, K; Tiemeier, H; Tremoli, E; van der Harst, P; Vestergaard, H; Vollenweider, P; Wareham, NJ; Weir, DR; Whitfield, JB; Wilson, JF; Tyrrell, J; Frayling, TM; Barroso, I; Boehnke, M; Deloukas, P; Fox, CS; Hirschhorn, JN; Hunter, DJ; Spector, TD; Strachan, DP; van Duijn, CM; Heid, IM; Mohlke, KL; Marchini, J; Loos, RJF; Kilpeläinen, TO; Liu, C-T; Borecki, IB; North, KE; Cupples, LA (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun, 8. p. 14977. ISSN 2041-1723 https://doi.org/10.1038/ncomms14977
SGUL Authors: Strachan, David Peter

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Abstract

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Item Type: Article
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: MD Multidisciplinary
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nat Commun
ISSN: 2041-1723
Language: eng
Dates:
DateEvent
26 April 2017Published
15 February 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 28443625
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108540
Publisher's version: https://doi.org/10.1038/ncomms14977

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