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Fifteen-Minute Consultation: The Complexities of Empiric Antibiotic Selection for Serious Bacterial Infections – a Practical Approach.

Bielicki, J; Cromwell, DA; Sharland, MR (2016) Fifteen-Minute Consultation: The Complexities of Empiric Antibiotic Selection for Serious Bacterial Infections – a Practical Approach. Archives of Disease in Childhood, 102 (3). pp. 117-123. ISSN 1468-2044 https://doi.org/10.1136/archdischild-2016-310527
SGUL Authors: Sharland, Michael Roy

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Abstract

Potentially life-threatening infections require immediate antibiotic therapy. Most early stage antibiotic treatment for these infections is empiric that is covering a range of possible target bacteria while awaiting culture results. Empiric antibiotic regimens need to reflect the epidemiology of most likely causative bacteria, type of infection and patient risk factors. Summary data from relevant isolates in similar patients helps to identify appropriate empiric regimens. At present, such data are mostly presented as hospital or other aggregate antibiograms, showing antimicrobial susceptibility testing results by bacterial species. However, a more suitable method is to calculate weighted incidence syndromic antibiograms (WISCAs) for different types of infections and regimens, allowing head-to-head comparisons of empiric regimens. Once there is confirmatory or negative microbiological evidence of infection, empiric regimens should be adapted to the identified bacterial species and susceptibilities or discontinued.

Item Type: Article
Additional Information: Copyright Article author (or their employer) 2016. Produced by BMJ Publishing Group Ltd under licence. This article has been accepted for publication in Archives of Disease in Childhood, available online at: http://dx.doi.org/10.1136/archdischild-2016-310527
Keywords: Pediatrics, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine, 1117 Public Health And Health Services
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Archives of Disease in Childhood
ISSN: 1468-2044
Dates:
DateEvent
1 June 2016Published
21 November 2016Published Online
1 November 2016Accepted
Publisher License: Publisher's own licence
URI: https://openaccess.sgul.ac.uk/id/eprint/108357
Publisher's version: https://doi.org/10.1136/archdischild-2016-310527

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