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Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection.

Luck, SE; Emery, VC; Atkinson, C; Sharland, M; Griffiths, PD (2016) Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection. Journal of Clinical Virology, 82. pp. 152-158. ISSN 1873-5967 https://doi.org/10.1016/j.jcv.2016.07.018
SGUL Authors: Sharland, Michael Roy Luck, Suzanne Elizabeth

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Abstract

BACKGROUND: Cytomegalovirus (CMV) is the most prevalent congenital infection in developed countries. A significant number of infected infants develop long-term neurodevelopmental and hearing impairment irrespective of whether disease is detectable at birth. Studies of viral load and replication dynamics have informed the treatment of CMV in adult populations but no similar data exist in neonates. OBJECTIVES: To study CMV virus kinetics in different body fluids of babies treated for congenital infection. STUDY DESIGN: CMV virus load was sequentially analyzed in blood, urine and saliva in 17 babies treated for symptomatic congenital CMV infection. RESULTS: Virus was detectable in the urine and saliva of all babies at baseline but in only 15/17 in blood. At the end of 6 weeks of antiviral treatment CMV remained detectable in 9/14 blood samples, 9/12 urine samples and 4/7 salivary swabs. Median half-life (T1/2) of virus decline in blood was 2.4 days (IQR 1.9-3.3) and basic reproductive number (Ro) was 2.3. Although T1/2 values were similar in urine and saliva to those observed in blood, virus dynamics differed both during and after treatment. CONCLUSIONS: T1/2 and Ro in blood in this group of neonates were similar to values derived from studies of immunocompromised adults. The persistent viremia observed in treated neonates cannot therefore be adequately explained by the virus dynamics early in treatment. The different dynamics exhibited in blood and urine suggests that studying changes in distinct body compartments may assist in further understanding long-term manifestations of disease.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Antiviral treatment, Congenital cytomegalovirus, Virus dynamics, Virus half-life, Virology, 1103 Clinical Sciences, 0605 Microbiology, 1108 Medical Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Journal of Clinical Virology
ISSN: 1873-5967
Language: eng
Dates:
DateEvent
1 September 2016Published
27 July 2016Published Online
27 July 2016Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 27500364
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108151
Publisher's version: https://doi.org/10.1016/j.jcv.2016.07.018

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