SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides.

Ashby, M; Petkova, A; Gani, J; Mikut, R; Hilpert, K (2016) Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides. Curr Top Med Chem, 17 (5). pp. 537-553. ISSN 1873-4294 https://doi.org/10.2174/1568026616666160713125555
SGUL Authors: Hilpert, Kai

[img]
Preview
PDF Accepted Version
Download (1MB) | Preview

Abstract

The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted in an urgent need to find new molecules that hold therapeutic promise against multidrug-resistant strains. Antimicrobial peptides have proven very effective against a variety of multidrug-resistant bacteria. Additionally, the low levels of resistance reported towards these molecules are an attractive feature for antimicrobial drug development. Here we summarise information on diverse peptide libraries used to discover or to optimize antimicrobial peptides. Chemical synthesized peptide libraries, for example split and mix method, tea bag method, multi-pin method and cellulose spot method are discussed. In addition biological peptide library screening methods are summarized, like phage display, bacterial display, mRNA-display and ribosomal display. A few examples are given for small peptide libraries, which almost exclusively follow a rational design of peptides of interest rather than a combinatorial approach.

Item Type: Article
Additional Information: The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1568026616666160713125555
Keywords: Medicinal & Biomolecular Chemistry, 0304 Medicinal And Biomolecular Chemistry
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Curr Top Med Chem
ISSN: 1873-4294
Language: ENG
Dates:
DateEvent
13 July 2016Published Online
14 November 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 27411326
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108126
Publisher's version: https://doi.org/10.2174/1568026616666160713125555

Actions (login required)

Edit Item Edit Item