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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin- resistant Staphylococcus aureus: Blurring of the traditional definitions

Lindsay, J; Bal, AM; Coombs, GW; Holden, MTG; Nimmo, GR; Tattevin, P; Skov, RL (2016) Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin- resistant Staphylococcus aureus: Blurring of the traditional definitions. Journal of Global Antimicrobial Resistance, 6. pp. 95-101. ISSN 2213-7165 https://doi.org/10.1016/j.jgar.2016.04.004
SGUL Authors: Lindsay, Jodi Anne

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Abstract

The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Journal of Global Antimicrobial Resistance
ISSN: 2213-7165
Dates:
DateEvent
1 September 2016Published
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
URI: https://openaccess.sgul.ac.uk/id/eprint/107971
Publisher's version: https://doi.org/10.1016/j.jgar.2016.04.004

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