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What do I need to know about penicillin antibiotics?

Barker, CI; Germovsek, E; Sharland, M (2017) What do I need to know about penicillin antibiotics? Archives of Disease in Childhood: Education and Practice Edition, 102 (1). pp. 44-50. ISSN 1743-0593 https://doi.org/10.1136/archdischild-2015-309068
SGUL Authors: Barker, Charlotte Ida Sophia

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Abstract

The penicillins remain the class of antibiotics most commonly prescribed to children worldwide. In an era when the risks posed by antimicrobial resistance are growing, an understanding of antibiotic pharmacology and how to apply these principles in clinical practice is increasingly important. This paper provides an overview of the pharmacology of penicillins, focusing on those aspects of pharmacokinetics, pharmacodynamics and toxicity that are clinically relevant in paediatric prescribing. Penicillin allergy is frequently reported but a detailed history of suspected adverse reactions is essential to identify whether a clinically relevant hypersensitivity reaction is likely or not. The importance of additional factors such as antibiotic palatability, concordance and stewardship are also discussed, highlighting their relevance to optimal prescribing of the penicillins for children.

Item Type: Article
Additional Information: Copyright Article author (or their employer) 2016. Produced by BMJ Publishing Group Ltd under licence. The published version of the article can be accessed here: http://ep.bmj.com/content/102/1/44
Keywords: Pediatrics, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Archives of Disease in Childhood: Education and Practice Edition
ISSN: 1743-0593
Dates:
DateEvent
8 June 2016Accepted
13 July 2016Published Online
18 January 2017Published
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
FP7/2007-2013 261060Seventh Framework Programmehttp://dx.doi.org/10.13039/501100004963
242146Seventh Framework Programmehttp://dx.doi.org/10.13039/501100004963
SP4650 GN1834Action Medical Researchhttp://dx.doi.org/10.13039/501100000317
URI: http://openaccess.sgul.ac.uk/id/eprint/107966
Publisher's version: https://doi.org/10.1136/archdischild-2015-309068

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