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Perinatal and long-term outcome in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta-analysis.

Scala, C; Familiari, A; Pinas, A; Papageorghiou, AT; Bhide, A; Thilaganathan, B; Khalil, A (2017) Perinatal and long-term outcome in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta-analysis. Ultrasound in Obstetetrics and Gynecology, 49 (4). pp. 450-459. ISSN 1469-0705 https://doi.org/10.1002/uog.15943
SGUL Authors: Papageorghiou, Aris Thilaganathan, Baskaran

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Abstract

OBJECTIVES: The majority of the studies have focused on the perinatal and long-term outcomes in fetuses with antenatal diagnosis of bilateral ventriculomegaly. The aim of this study was to undertake a systematic review and meta-analysis to quantify the perinatal and long-term outcome of fetuses diagnosed with isolated unilateral ventriculomegaly during the second- or third- trimester of pregnancy. METHODS: Medline, and Embase and The Cochrane Library were searched electronically. The outcomes investigated included incidence of aneuploidy, congenital infections, progression, associated brain and extra-brain abnormalities for the apparently isolated unilateral ventriculomegaly cases and neurodevelopmental delay for both apparently and truly isolated unilateral ventriculomegaly cases. Sensitivity analysis was performed according to whether the ventriculomegaly was mild or severe. Reference lists of relevant articles and reviews were hand-searched for additional reports. Cohort and case-control studies were included. Meta-analyses of proportions were used. Between-study heterogeneity was assessed using the I(2) test. RESULTS: The search yielded 2053 citations. Full text was retrieved for 202 and the 11 studies were included in the systematic review. In fetuses with apparently isolated unilateral ventriculomegaly there were no chromosomal abnormalities and the rate of congenital infections was 8.2% (95% CI 3.6-14.5). The prevalence of MRI-detected additional brain abnormalities prenatally and postnatally was 5% (95% CI, 0.2-16) and 6.4%, (95% CI, 0.3-19.4), respectively. The incidence of abnormal neurodevelopmental status in apparently isolated cases measuring <15 mm was 5.9% (95% CI, 2.2-11.2), while it was 7.0% (95% CI, 3.2-12.2) in fetuses with truly isolated unilateral ventriculomegaly. Most of the cases reported (93%) were mild ventriculomegaly, and therefore the outcomes were similar to those above. CONCLUSIONS: The prevalence of aneuploidy, congenital infections and neurodevelopmental delay in fetuses with a prenatal diagnosis of isolated unilateral ventriculomegaly is likely to be low.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Scala, C., Familiari, A., Pinas, A., Papageorghiou, A. T., Bhide, A., Thilaganathan, B. and Khalil, A. (2017), Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systematic review and meta-analysis. Ultrasound Obstet Gynecol, 49: 450–459. doi:10.1002/uog.15943, which has been published in final form at http://doi.org/10.1002/uog.15943. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: long-term outcomes, neurodevelopmental delay, perinatal outcomes, prenatal diagnosis, unilateral ventriculomegaly, Obstetrics & Reproductive Medicine, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Ultrasound in Obstetetrics and Gynecology
ISSN: 1469-0705
Language: ENG
Dates:
DateEvent
3 April 2017Published
19 April 2016Published Online
14 April 2016Accepted
Publisher License: Publisher's own licence
PubMed ID: 27091707
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107859
Publisher's version: https://doi.org/10.1002/uog.15943

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