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Psychopharmacology of topiramate: from epilepsy to bipolar disorder.

Mula, M; Cavanna, AE; Monaco, F (2006) Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatric Disease and Treatment, 2 (4). pp. 475-488. ISSN 1176-6328
SGUL Authors: Mula, Marco

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Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially those displaying rapid-cycling and mixed states. This paper reviews the multiple mechanisms of action and the tolerability profile of TPM in the light of its therapeutic potential in affective disorders. Studies of TPM in bipolar disorder are evaluated, and the efficacy and tolerability issues as a mood stabilizing agent are discussed.

Item Type: Article
Additional Information: © 2006 Mula et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (
Keywords: antiepileptic drugs, bipolar disorder, epilepsy, mood stabilizer, topiramate, Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Neuropsychiatric Disease and Treatment
ISSN: 1176-6328
Language: eng
15 December 2006Published
Publisher License: Creative Commons: Attribution-Noncommercial 3.0
PubMed ID: 19412496
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