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Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains

Ahmed-Jushuf, F; Jiwa, NS; Arwani, AS; Foot, P; Bridges, LR; Kalaria, RN; Esiri, MM; Hainsworth, AH (2016) Age-dependent expression of VEGFR2 in deep brain arteries in small vessel disease, CADASIL, and healthy brains. Neurobiology of Aging, 42. pp. 110-115. ISSN 0197-4580 https://doi.org/10.1016/j.neurobiolaging.2016.03.002
SGUL Authors: Hainsworth, Atticus Henry

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Abstract

Vascular myocytes are central to brain aging. Small vessel disease (SVD; arteriolosclerosis) is a widespread cause of lacunar stroke and vascular dementia, and is characterised by fibrosis and depletion of vascular myocytes in small penetrating arteries. Vascular endothelial growth factor (VEGF) is associated with brain aging, and VEGFR2 is a potent determinant of cell fate. Here, we tested whether VEGFR2 in vascular myocytes is associated with older age and SVD in human brain. VEGFR2 immunolabelling in deep grey matter was assessed in older people with or without moderate-severe SVD, or in younger people without brain pathology or with a monogenic form of SVD (CADASIL). All cases were without Alzheimer’s disease pathology. Myocyte VEGFR2 was associated with increasing age (p=0.0026) but not with SVD pathology or with sclerotic index or blood vessel density. We conclude that VEGFR2 is consistently expressed in small artery myocytes of older people, and may mediate effects of VEGF on brain vascular aging.

Item Type: Article
Additional Information: © 2016 Elsevier Inc. All rights reserved
Keywords: Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: Neurobiology of Aging
ISSN: 0197-4580
Dates:
DateEvent
1 June 2016Published
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
PG146/151Alzheimer’s SocietyUNSPECIFIED
20140901Alzheimer's Drug Discovery FoundationUNSPECIFIED
PPG2014A-8Alzheimer's Research UKUNSPECIFIED
URI: https://openaccess.sgul.ac.uk/id/eprint/107789
Publisher's version: https://doi.org/10.1016/j.neurobiolaging.2016.03.002

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