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Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants.

Hesseling, AC; Blakney, AK; Jones, CE; Esser, MM; de Beer, C; Kuhn, L; Cotton, MF; Jaspan, HB (2016) Delayed BCG immunization does not alter antibody responses to EPI vaccines in HIV-exposed and -unexposed South African infants. Vaccine, 34 (32). pp. 3702-3709. ISSN 1873-2518
SGUL Authors: Jones, Christine Elizabeth

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BACKGROUND: Bacille Calmette-Guérin (BCG) is routinely given at birth in tuberculosis-endemic settings due to its protective effect against disseminated tuberculosis in infants. BCG is however contraindicated in HIV-infected infants. We investigated whether delaying BCG vaccination to 14 weeks of age affected vaccine-induced antibody responses to Haemophilus influenzae type b (Hib)-conjugate, pertussis, tetanus and Hepatitis B (HBV) vaccines, in HIV-exposed uninfected (HEU) and -unexposed uninfected (HUU) infants. METHODS: Infants were randomized to receive BCG at birth or at 14 weeks of age. Blood was taken at 14, 24, and 52 weeks of age and analyzed for Hib, pertussis, tetanus and HBV specific antibodies. RESULTS: BCG was given either at birth (106 infants, 51 HEU) or at 14 weeks of age (74 infants, 50 HEU). The timing of BCG vaccination did not influence the antibody response to any antigen studied. However, in a non-randomized comparison, HEU infants had higher Hib antibody concentrations at weeks 14 and 24 (p=0.001 and <0.001, respectively) and pertussis at week 24 (p=0.003). Conversely, HEU infants had lower antibody concentrations to HBV at 14 and 52 weeks (p=0.032 and p=0.031) with no differences in tetanus titres. CONCLUSIONS: HIV exposure, but not the timing of BCG vaccination, was associated with antibody concentrations to Hib, pertussis, HBV and tetanus primary immunization. CLINICAL TRIAL REGISTRATION: DOH-27-1106-1520.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Keywords: BCG, HIV-exposed, Humoral immunity, Infants, South Africa, Antibodies, Bacterial, Antibodies, Viral, Antibody Formation, BCG Vaccine, Diphtheria-Tetanus-Pertussis Vaccine, Female, HIV Infections, Haemophilus Vaccines, Humans, Immunization Schedule, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Poliovirus Vaccine, Oral, Pregnancy, Single-Blind Method, South Africa, Tetanus Toxoid, Time Factors, Virology, 06 Biological Sciences, 07 Agricultural And Veterinary Sciences, 11 Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Vaccine
ISSN: 1873-2518
Language: eng
12 July 2016Published
4 April 2016Published Online
21 March 2016Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Project IDFunderFunder ID
NR-0006Thrasher Research Fund
ZQ-00-8-520-0123-0-00Elizabeth Glaser Pediatric AIDS Foundation
PubMed ID: 27055019
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