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Transcription factor LSF (TFCP2) inhibits melanoma growth.

Goto, Y; Yajima, I; Kumasaka, M; Ohgami, N; Tanaka, A; Tsuzuki, T; Inoue, Y; Fukushima, S; Ihn, H; Kyoya, M; et al. Goto, Y; Yajima, I; Kumasaka, M; Ohgami, N; Tanaka, A; Tsuzuki, T; Inoue, Y; Fukushima, S; Ihn, H; Kyoya, M; Ohashi, H; Kawakami, T; Bennett, DC; Kato, M (2015) Transcription factor LSF (TFCP2) inhibits melanoma growth. Oncotarget, 7 (3). pp. 2379-2390. ISSN 1949-2553 https://doi.org/10.18632/oncotarget.6230
SGUL Authors: Bennett, Dorothy Catherine

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Abstract

Late SV40 factor 3 (LSF), a transcription factor, contributes to human hepatocellular carcinoma (HCC). However, decreased expression level of LSF in skin melanoma compared to that in benign melanocytic tumors and nevi in mice and humans was found in this study. Anchorage-dependent and -independent growth of melanoma cells was suppressed by LSF overexpression through an increased percentage of G1 phase cells and an increased p21CIP1 expression level in vitro and in vivo. Anchorage-dependent growth in LSF-overexpressed melanoma cells was promoted by depletion of LSF in the LSF-overexpressed cells. Integrated results of our EMSA and chromatin immunoprecipitation assays showed binding of LSF within a 150-bp upstream region of the transcription start site of p21CIP1 in melanoma cells. Taken together, our results suggest potential roles of LSF as a growth regulator through control of the transcription of p21CIP1 in melanocytes and melanoma cells as well as a biomarker for nevus.

Item Type: Article
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: CDKN1A, TFCP2, cell cycle, melanoma, transcription factor LSF, melanoma, transcription factor LSF, TFCP2, CDKN1A, cell cycle
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: Oncotarget
ISSN: 1949-2553
Language: eng
Dates:
DateEvent
25 October 2015Published
Publisher License: Creative Commons: Attribution 3.0
PubMed ID: 26506241
Web of Science ID: WOS:000369951800018
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107707
Publisher's version: https://doi.org/10.18632/oncotarget.6230

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