SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

HIV-exposed uninfected infants: new global challenges in the era of paediatric HIV elimination

Evans, C; Jones, CE; Prendergast, AJ (2016) HIV-exposed uninfected infants: new global challenges in the era of paediatric HIV elimination. Lancet Infectious Diseases, 16 (6). e92-e107. ISSN 1474-4457 https://doi.org/10.1016/S1473-3099(16)00055-4
SGUL Authors: Jones, Christine Elizabeth

[img] Microsoft Word (.docx) Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (364kB)

Abstract

The number of infants infected with HIV is declining with the rise in interventions for the elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV through their HIV-infected mothers is increasing. Interest in the health outcomes of HIV-exposed, uninfected infants has grown in the past decade, with several studies suggesting that these infants have increased mortality rates, increased infectious morbidity, and impaired growth compared with HIV-unexposed infants. However, heterogeneous results might reflect the inherent challenges in studies of HIV-exposed, uninfected infants, which need large populations with appropriate, contemporaneous comparison groups and repeated HIV testing throughout the period of breastfeeding. We review the effects of HIV exposure on mortality, morbidity, and growth, discuss the immunological abnormalities identified so far, and provide an overview of interventions that could be effective in this susceptible population. As the number of infants infected with HIV declines, the health needs of HIV-exposed, uninfected infants should be prioritised further, to ensure that post-2015 Sustainable Development Goals are achieved.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: 1103 Clinical Sciences, 1108 Medical Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Lancet Infectious Diseases
ISSN: 1474-4457
Dates:
DateEvent
21 January 2016Accepted
31 March 2016Published Online
June 2016Published
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
093768/Z/10/ZWellcome TrustUNSPECIFIED
URI: https://openaccess.sgul.ac.uk/id/eprint/107658
Publisher's version: https://doi.org/10.1016/S1473-3099(16)00055-4

Actions (login required)

Edit Item Edit Item