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Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain.

Grech-Sollars, M; Hales, PW; Miyazaki, K; Raschke, F; Rodriguez, D; Wilson, M; Gill, SK; Banks, T; Saunders, DE; Clayden, JD; et al. Grech-Sollars, M; Hales, PW; Miyazaki, K; Raschke, F; Rodriguez, D; Wilson, M; Gill, SK; Banks, T; Saunders, DE; Clayden, JD; Gwilliam, MN; Barrick, TR; Morgan, PS; Davies, NP; Rossiter, J; Auer, DP; Grundy, R; Leach, MO; Howe, FA; Peet, AC; Clark, CA (2015) Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain. NMR Biomed, 28 (4). pp. 468-485. ISSN 1099-1492 https://doi.org/10.1002/nbm.3269
SGUL Authors: Barrick, Thomas Richard Howe, Franklyn Arron

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Abstract

The purpose of this work was to assess the reproducibility of diffusion imaging, and in particular the apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters and diffusion tensor imaging (DTI) parameters, across multiple centres using clinically available protocols with limited harmonization between sequences. An ice-water phantom and nine healthy volunteers were scanned across fives centres on eight scanners (four Siemens 1.5T, four Philips 3T). The mean ADC, IVIM parameters (diffusion coefficient D and perfusion fraction f) and DTI parameters (mean diffusivity MD and fractional anisotropy FA), were measured in grey matter, white matter and specific brain sub-regions. A mixed effect model was used to measure the intra- and inter-scanner coefficient of variation (CV) for each of the five parameters. ADC, D, MD and FA had a good intra- and inter-scanner reproducibility in both grey and white matter, with a CV ranging between 1% and 7.4%; mean 2.6%. Other brain regions also showed high levels of reproducibility except for small structures such as the choroid plexus. The IVIM parameter f had a higher intra-scanner CV of 8.4% and inter-scanner CV of 24.8%. No major difference in the inter-scanner CV for ADC, D, MD and FA was observed when analysing the 1.5T and 3T scanners separately. ADC, D, MD and FA all showed good intra-scanner reproducibility, with the inter-scanner reproducibility being comparable or faring slightly worse, suggesting that using data from multiple scanners does not have an adverse effect compared with using data from the same scanner. The IVIM parameter f had a poorer inter-scanner CV when scanners of different field strengths were combined, and the parameter was also affected by the scan acquisition resolution. This study shows that the majority of diffusion MRI derived parameters are robust across 1.5T and 3T scanners and suitable for use in multi-centre clinical studies and trials.

Item Type: Article
Additional Information: © 2015 The Authors NMR in Biomedicine Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: MRI, brain, diffusion, multi-centre, reproducibility, Nuclear Medicine & Medical Imaging, 1103 Clinical Sciences, 0304 Medicinal And Biomolecular Chemistry, 0903 Biomedical Engineering
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: NMR Biomed
ISSN: 1099-1492
Language: eng
Dates:
DateEvent
April 2015Published
19 March 2015Published Online
20 January 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
C7809/A10342Cancer Research UKUNSPECIFIED
PubMed ID: 25802212
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107439
Publisher's version: https://doi.org/10.1002/nbm.3269

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