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Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults.

Mula, M (2013) Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. Drug Design, Development and Therapy, 7. pp. 397-402. ISSN 1177-8881 https://doi.org/10.2147/DDDT.S43612
SGUL Authors: Mula, Marco

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Abstract

Epilepsy is one of the most common neurologic disorders, affecting about 50 million people around the world. It is recognized that around 50% of patients with newly diagnosed epilepsy become seizure-free with the first drug treatment, so the choice of first antiepileptic drug is crucial. This paper provides a comprehensive overview of zonisamide as monotherapy for partial seizures, with special attention to the possibility of a once-daily regimen. The available data suggest that zonisamide is an effective and well tolerated option as monotherapy. Once-daily dosing is indicated, considering the long plasma half-life and linear pharmacokinetics of the drug. Zonisamide 300 mg was shown to be noninferior to carbamazepine 600 mg in terms of efficacy and safety, but even lower doses may be effective. Finally, the broad spectrum of efficacy in different seizure types, the low drug interaction potential, and the possibility of weight loss make zonisamide a preferred option in many epilepsy practices. Further data on monotherapy, especially in special populations, such as women of childbearing potential, are needed.

Item Type: Article
Additional Information: © 2013 Mula, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
Keywords: epilepsy, monotherapy, zonisamide, Anticonvulsants, Drug Administration Schedule, Epilepsies, Partial, Humans, Isoxazoles, 1115 Pharmacology And Pharmaceutical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Drug Design, Development and Therapy
ISSN: 1177-8881
Language: eng
Dates:
DateEvent
13 May 2013Published
PubMed ID: 23700365
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/107331
Publisher's version: https://doi.org/10.2147/DDDT.S43612

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