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Common variants associated with plasma triglycerides and risk for coronary artery disease.

Do, R; Willer, CJ; Schmidt, EM; Sengupta, S; Gao, C; Peloso, GM; Gustafsson, S; Kanoni, S; Ganna, A; Chen, J; et al. Do, R; Willer, CJ; Schmidt, EM; Sengupta, S; Gao, C; Peloso, GM; Gustafsson, S; Kanoni, S; Ganna, A; Chen, J; Buchkovich, ML; Mora, S; Beckmann, JS; Bragg-Gresham, JL; Chang, HY; Demirkan, A; Den Hertog, HM; Donnelly, LA; Ehret, GB; Esko, T; Feitosa, MF; Ferreira, T; Fischer, K; Fontanillas, P; Fraser, RM; Freitag, DF; Gurdasani, D; Heikkilä, K; Hyppönen, E; Isaacs, A; Jackson, AU; Johansson, A; Johnson, T; Kaakinen, M; Kettunen, J; Kleber, ME; Li, X; Luan, J; Lyytikäinen, LP; Magnusson, PK; Mangino, M; Mihailov, E; Montasser, ME; Müller-Nurasyid, M; Nolte, IM; O'Connell, JR; Palmer, CD; Perola, M; Petersen, AK; Sanna, S; Saxena, R; Service, SK; Shah, S; Shungin, D; Sidore, C; Song, C; Strawbridge, RJ; Surakka, I; Tanaka, T; Teslovich, TM; Thorleifsson, G; Van den Herik, EG; Voight, BF; Volcik, KA; Waite, LL; Wong, A; Wu, Y; Zhang, W; Absher, D; Asiki, G; Barroso, I; Been, LF; Bolton, JL; Bonnycastle, LL; Brambilla, P; Burnett, MS; Cesana, G; Dimitriou, M; Doney, AS; Döring, A; Elliott, P; Epstein, SE; Eyjolfsson, GI; Gigante, B; Goodarzi, MO; Grallert, H; Gravito, ML; Groves, CJ; Hallmans, G; Hartikainen, AL; Hayward, C; Hernandez, D; Hicks, AA; Holm, H; Hung, YJ; Illig, T; Jones, MR; Kaleebu, P; Kastelein, JJ; Khaw, KT; Kim, E; Klopp, N; Komulainen, P; Kumari, M; Langenberg, C; Lehtimäki, T; Lin, SY; Lindström, J; Loos, RJ; Mach, F; McArdle, WL; Meisinger, C; Mitchell, BD; Müller, G; Nagaraja, R; Narisu, N; Nieminen, TV; Nsubuga, RN; Olafsson, I; Ong, KK; Palotie, A; Papamarkou, T; Pomilla, C; Pouta, A; Rader, DJ; Reilly, MP; Ridker, PM; Rivadeneira, F; Rudan, I; Ruokonen, A; Samani, N; Scharnagl, H; Seeley, J; Silander, K; Stančáková, A; Stirrups, K; Swift, AJ; Tiret, L; Uitterlinden, AG; van Pelt, LJ; Vedantam, S; Wainwright, N; Wijmenga, C; Wild, SH; Willemsen, G; Wilsgaard, T; Wilson, JF; Young, EH; Zhao, JH; Adair, LS; Arveiler, D; Assimes, TL; Bandinelli, S; Bennett, F; Bochud, M; Boehm, BO; Boomsma, DI; Borecki, IB; Bornstein, SR; Bovet, P; Burnier, M; Campbell, H; Chakravarti, A; Chambers, JC; Chen, YD; Collins, FS; Cooper, RS; Danesh, J; Dedoussis, G; de Faire, U; Feranil, AB; Ferrières, J; Ferrucci, L; Freimer, NB; Gieger, C; Groop, LC; Gudnason, V; Gyllensten, U; Hamsten, A; Harris, TB; Hingorani, A; Hirschhorn, JN; Hofman, A; Hovingh, GK; Hsiung, CA; Humphries, SE; Hunt, SC; Hveem, K; Iribarren, C; Järvelin, MR; Jula, A; Kähönen, M; Kaprio, J; Kesäniemi, A; Kivimaki, M; Kooner, JS; Koudstaal, PJ; Krauss, RM; Kuh, D; Kuusisto, J; Kyvik, KO; Laakso, M; Lakka, TA; Lind, L; Lindgren, CM; Martin, NG; März, W; McCarthy, MI; McKenzie, CA; Meneton, P; Metspalu, A; Moilanen, L; Morris, AD; Munroe, PB; Njølstad, I; Pedersen, NL; Power, C; Pramstaller, PP; Price, JF; Psaty, BM; Quertermous, T; Rauramaa, R; Saleheen, D; Salomaa, V; Sanghera, DK; Saramies, J; Schwarz, PE; Sheu, WH; Shuldiner, AR; Siegbahn, A; Spector, TD; Stefansson, K; Strachan, DP; Tayo, BO; Tremoli, E; Tuomilehto, J; Uusitupa, M; van Duijn, CM; Vollenweider, P; Wallentin, L; Wareham, NJ; Whitfield, JB; Wolffenbuttel, BH; Altshuler, D; Ordovas, JM; Boerwinkle, E; Palmer, CN; Thorsteinsdottir, U; Chasman, DI; Rotter, JI; Franks, PW; Ripatti, S; Cupples, LA; Sandhu, MS; Rich, SS; Boehnke, M; Deloukas, P; Mohlke, KL; Ingelsson, E; Abecasis, GR; Daly, MJ; Neale, BM; Kathiresan, S (2013) Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45 (11). pp. 1345-1352. ISSN 1546-1718 https://doi.org/10.1038/ng.2795
SGUL Authors: Strachan, David Peter

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Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

Item Type: Article
Additional Information: Author’s manuscript is made available for academic research only, and cannot be used for commercial purposes without prior permission of the copyright holders. Made available here with permission from the publisher.
Keywords: Biological Transport, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Triglycerides, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, ISCHEMIC-HEART-DISEASE, HIGH-DENSITY-LIPOPROTEIN, TYPE-2 DIABETES-MELLITUS, MENDELIAN RANDOMIZATION, CARDIOVASCULAR-DISEASE, GENETIC EPIDEMIOLOGY, CHOLESTEROL LEVELS, LOCI, CONTRIBUTE, THERAPY, Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nature Genetics
ISSN: 1546-1718
Language: eng
Dates:
DateEvent
November 2013Published
PubMed ID: 24097064
Web of Science ID: WOS:000326384100015
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107307
Publisher's version: https://doi.org/10.1038/ng.2795

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