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Kv7 and Kv11 channels in myometrial regulation.

Greenwood, IA; Tribe, RM (2014) Kv7 and Kv11 channels in myometrial regulation. Experimental Physiology, 99 (3). pp. 503-509. ISSN 1469-445X https://doi.org/10.1113/expphysiol.2013.075754
SGUL Authors: Greenwood, Iain Andrew

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Abstract

Ion channels play a key role in defining myometrial contractility. Modulation of ion channel populations is proposed to underpin gestational changes in uterine contractility associated with the transition from uterine quiescence to active labour. Of the myriad ion channels present in the uterus, this article will focus upon potassium channels encoded by the KCNQ genes and ether-à-go-go-related (ERG) genes. Voltage-gated potassium channels encoded by KCNQ and ERG (termed Kv7 and Kv11, respectively) are accepted as major determinants of neuronal excitability and the duration of the cardiac action potential. However, there is now growing appreciation that these ion channels have a major functional impact in vascular and non-vascular smooth muscle. Moreover, Kv7 channels may be potential therapeutic targets for the treatment of preterm labour.

Item Type: Article
Additional Information: ©2013 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Adult, Ether-A-Go-Go Potassium Channels, Female, Humans, KCNQ Potassium Channels, Muscle, Smooth, Myometrium, Neural Pathways, Potassium Channels, Pregnancy, Uterus, Science & Technology, Life Sciences & Biomedicine, Physiology, PORTAL-VEIN MYOCYTES, ACTIVATED CHLORIDE CHANNEL, SMOOTH-MUSCLE-CELLS, K+-CHANNELS, CONTRACTILE ACTIVITY, INTERSTITIAL-CELLS, POTASSIUM CHANNELS, RAT UTERUS, FUNCTIONAL-CHARACTERIZATION, MOLECULAR-IDENTIFICATION, 1116 Medical Physiology, 0606 Physiology, 1106 Human Movement And Sports Science
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular (INCCVA)
Journal or Publication Title: Experimental Physiology
ISSN: 1469-445X
Language: eng
Dates:
DateEvent
1 March 2014Published
PubMed ID: 24121285
Web of Science ID: WOS:000332139900007
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107256
Publisher's version: https://doi.org/10.1113/expphysiol.2013.075754

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