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Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.

Carpenter, JP; Alpendurada, F; Deac, M; Maceira, A; Garbowski, M; Kirk, P; Walker, JM; Porter, JB; Shah, F; Banya, W; et al. Carpenter, JP; Alpendurada, F; Deac, M; Maceira, A; Garbowski, M; Kirk, P; Walker, JM; Porter, JB; Shah, F; Banya, W; He, T; Smith, GC; Pennell, DJ (2010) Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload. Journal of Cardiovascular Magnetic Resonance, 12 (24). ISSN 1532-429X https://doi.org/10.1186/1532-429X-12-24
SGUL Authors: He, Taigang

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Abstract

AIM: We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload. METHODS AND RESULTS: RV volumes, EF and mass were measured in 80 TM patients who had no myocardial iron overload (myocardial T2* > 20 ms by cardiovascular magnetic resonance). All patients were receiving deferoxamine chelation and none had evidence of pulmonary hypertension or other cardiovascular comorbidity. Forty age and sex matched healthy non-anemic volunteers acted as controls. The mean RV EF was higher in TM patients than controls (males 66.2 +/- 4.1% vs 61.6 +/- 6%, p = 0.0009; females 66.3 +/- 5.1% vs 62.6 +/- 6.4%, p = 0.017), which yielded a raised lower threshold of normality for RV EF in TM patients (males 58.0% vs 50.0% and females 56.4% vs 50.1%). RV end-diastolic volume index was higher in male TM patients (mean 98.1 +/- 17.3 mL vs 88.4 +/- 11.2 mL/m2, p = 0.027), with a higher upper limit (132 vs 110 mL/m2) but this difference was of borderline significance for females (mean 86.5 +/- 13.6 mL vs 80.3 +/- 12.8 mL/m2, p = 0.09, with upper limit of 113 vs 105 mL/m2). The cardiac index was raised in TM patients (males 4.8 +/- 1.0 L/min vs 3.4 +/- 0.7 L/min, p < 0.0001; females 4.5 +/- 0.8 L/min vs 3.2 +/- 0.8 L/min, p < 0.0001). No differences in RV mass index were identified. CONCLUSION: The normal ranges for functional RV parameters in TM patients with no evidence of myocardial iron overload differ from healthy non-anemic controls. The new reference RV ranges are important for determining the functional effects of myocardial iron overload in TM patients.

Item Type: Article
Additional Information: © 2010 Carpenter et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Blood Transfusion, Case-Control Studies, Deferoxamine, Female, Heart Ventricles, Hemoglobins, Humans, Iron, Iron Chelating Agents, Magnetic Resonance Imaging, Cine, Male, Predictive Value of Tests, Reference Values, Retrospective Studies, Stroke Volume, Ventricular Dysfunction, Right, Ventricular Function, Right, Young Adult, beta-Thalassemia, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, CARDIOVASCULAR MAGNETIC-RESONANCE, BODY-SURFACE AREA, PULMONARY-ARTERY PRESSURE, HEART-FAILURE, EJECTION FRACTION, BETA-THALASSEMIA, DIASTOLIC FUNCTION, INTERSTUDY REPRODUCIBILITY, GREAT-ARTERIES, SURVIVAL, Nuclear Medicine & Medical Imaging, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Language: eng
Dates:
DateEvent
23 April 2010Published
PubMed ID: 20416084
Web of Science ID: WOS:000277620600001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107215
Publisher's version: https://doi.org/10.1186/1532-429X-12-24

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