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Age differences in fMRI adaptation for sound identity and location

Grady, CL; Charlton, R; He, Y; Alain, C (2011) Age differences in fMRI adaptation for sound identity and location. FRONTIERS IN HUMAN NEUROSCIENCE, 5 (24). pp. 1-12. ISSN 1662-5161 https://doi.org/10.3389/fnhum.2011.00024
SGUL Authors: Charlton, Rebecca Ann

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Abstract

We explored age differences in auditory perception by measuring fMRI adaptation of brain activity to repetitions of sound identity (what) and location (where), using meaningful environmental sounds. In one condition, both sound identity and location were repeated allowing us to assess non-specific adaptation. In other conditions, only one feature was repeated (identity or location) to assess domain-specific adaptation. Both young and older adults showed comparable non-specific adaptation (identity and location) in bilateral temporal lobes, medial parietal cortex, and subcortical regions. However, older adults showed reduced domain-specific adaptation to location repetitions in a distributed set of regions, including frontal and parietal areas, and to identity repetition in anterior temporal cortex. We also re-analyzed data from a previously published 1-back fMRI study, in which participants responded to infrequent repetition of the identity or location of meaningful sounds. This analysis revealed age differences in domain-specific adaptation in a set of brain regions that overlapped substantially with those identified in the adaptation experiment. This converging evidence of reductions in the degree of auditory fMRI adaptation in older adults suggests that the processing of specific auditory “what” and “where” information is altered with age, which may influence cognitive functions that depend on this processing.

Item Type: Article
Additional Information: Copyright: © 2011 Grady, Charlton, He and Alain. This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Keywords: adaptation, aging, auditory system, fMRI, spatial localization, Science & Technology, Social Sciences, Life Sciences & Biomedicine, Neurosciences, Psychology, Neurosciences & Neurology, NEUROSCIENCES, PSYCHOLOGY, HUMAN AUDITORY-CORTEX, PARTIAL LEAST-SQUARES, WORKING-MEMORY, REPETITION SUPPRESSION, ENVIRONMENTAL SOUNDS, SELECTIVE ATTENTION, STIMULUS REPETITION, NEURAL ACTIVITY, BRAIN ACTIVITY, TEMPORAL-LOBE
Journal or Publication Title: FRONTIERS IN HUMAN NEUROSCIENCE
ISSN: 1662-5161
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Dates:
DateEvent
11 March 2011Published
Web of Science ID: WOS:000290214500001
URI: http://openaccess.sgul.ac.uk/id/eprint/107139
Publisher's version: https://doi.org/10.3389/fnhum.2011.00024

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