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Haemophilus influenzae type b reemergence after combination immunization

Johnson, NG; Ruggeberg, JU; Balfour, GF; Lee, YC; Liddy, H; Irving, D; Sheldon, J; Slack, MP; Pollard, AJ; Heath, PT (2006) Haemophilus influenzae type b reemergence after combination immunization. EMERGING INFECTIOUS DISEASES, 12 (6). 937 - 941. ISSN 1080-6040 https://doi.org/10.3201/eid1206.051451
SGUL Authors: Heath, Paul Trafford

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Abstract

An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phos- phate antibody concentration and avidity before and after a Hib booster in 176 children 2–4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertus- sis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody con- centrations before and avidity indices after vaccination were low (geometric mean concentration 0.46μg/mL, 95% confidence interval [CI] 0.36–0.58; geometric mean avidity index 0.16, 95% CI 0.14–0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p<0.001, respectively). Hib was found in 2.1% (95% CI 0.7%–6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concen- tration and avidity

Item Type: Article
Additional Information: Emerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, all materials published in Emerging Infectious Diseases are in the public domain and can be used without permission.
Keywords: Antibodies, Viral, Antibody Affinity, Bacterial Capsules, Child, Preschool, Diphtheria-Tetanus-acellular Pertussis Vaccines, Great Britain, Haemophilus Infections, Haemophilus Vaccines, Haemophilus influenzae type b, Humans, Immunization, Pharynx, Polysaccharides, Bacterial, Statistics, Nonparametric, Vaccines, Conjugate, Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, IMMUNOLOGY, INFECTIOUS DISEASES, ACELLULAR PERTUSSIS, INFANT IMMUNIZATION, CONJUGATE VACCINES, UNITED-KINGDOM, TETANUS, VACCINATION, DIPHTHERIA, ANTIBODY, IMMUNOGENICITY, SAFETY, Microbiology, 1108 Medical Microbiology, 1117 Public Health And Health Services, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: EMERGING INFECTIOUS DISEASES
ISSN: 1080-6040
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Dates:
DateEvent
1 June 2006Published
Web of Science ID: WOS:000237829900009
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URI: http://openaccess.sgul.ac.uk/id/eprint/107131
Publisher's version: https://doi.org/10.3201/eid1206.051451

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