SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study

Mehta, RS; Rodriguez, A; Chico, M; Guadalupe, I; Broncano, N; Sandoval, C; Tupiza, F; Mitre, E; Cooper, PJ (2012) Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study. PLOS NEGLECTED TROPICAL DISEASES, 6 (7). e1753 (1)- e1753 (6). ISSN 1935-2735 https://doi.org/10.1371/journal.pntd.0001753
SGUL Authors: Cooper, Philip John

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Available under License St George's repository terms & conditions.

Download (127kB) | Preview

Abstract

Background: Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection. Methods and Findings: We did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7 months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls without. Exposure was defined as maternal infection with A. lumbricoides and/or T. trichiura, detected during the third trimester of pregnancy. The analysis was restricted to households with a documented infection to control for infection risk. Children of mothers with STH infections had a greater risk of infection compared to children of uninfected mothers (adjusted OR 2.61, 95% CI: 1.88–3.63, p,0.001). This effect was particularly strong in children of mothers with both STH infections (adjusted OR: 5.91, 95% CI: 3.55–9.81, p,0.001). Newborns of infected mothers had greater levels of plasma IL-10 than those of uninfected mothers (p = 0.033), and there was evidence that cord blood IL-10 was increased among newborns who became infected later in childhood (p = 0.060). Conclusion: Our data suggest that maternal STH infections increase susceptibility to infection during early childhood, an effect that was associated with elevated IL-10 in cord plasma.

Item Type: Article
Additional Information: This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Keywords: Animals, Ascariasis, Ascaris lumbricoides, Case-Control Studies, Child, Preschool, Cohort Studies, Disease Susceptibility, Ecuador, Female, Humans, Infant, Interleukin-10, Male, Pregnancy, Pregnancy Complications, Parasitic, Risk Assessment, Trichuriasis, Trichuris, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, Tropical Medicine, PARASITOLOGY, TROPICAL MEDICINE, ASCARIS-LUMBRICOIDES, RISK-FACTORS, IN-UTERO, IMMUNE HYPORESPONSIVENESS, WUCHERERIA-BANCROFTI, HELMINTH INFECTIONS, RURAL AREA, SENSITIZATION, DISEASES, MALARIA, Tropical Medicine, Biological Sciences, Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLOS NEGLECTED TROPICAL DISEASES
ISSN: 1935-2735
Related URLs:
Dates:
DateEvent
1 July 2012Published
Web of Science ID: WOS:000307101900040
URI: https://openaccess.sgul.ac.uk/id/eprint/107054
Publisher's version: https://doi.org/10.1371/journal.pntd.0001753

Actions (login required)

Edit Item Edit Item