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Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

Krishna, S; Woodrow, CJ; Staines, HM; Haynes, RK; Mercereau-Puijalon, O (2006) Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance. TRENDS IN MOLECULAR MEDICINE, 12 (5). 200 - 205. ISSN 1471-4914 https://doi.org/10.1016/j.molmed.2006.03.005
SGUL Authors: Krishna, Sanjeev Staines, Henry Michael Woodrow, Charles Jonathan

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Abstract

There are more than half a billion cases of malaria every year. Combinations of an artemisinin with other antimalarial drugs are now recommended treatments for Plasmodium falciparum malaria in most endemic areas. These treatment regimens act rapidly to relieve symptoms and effect cure. There is considerable controversy on how artemisinins work and over emerging indications of resistance to this class of antimalarial drugs. Several individual molecules have been proposed as targets for artemisinins, in addition to the idea that artemisinins might have many targets at the same time. Our suggestion that artemisinins inhibit the parasite-encoded sarco–endoplasmic reticulum Ca2+-ATPase (SERCA) PfATP6 has gained support from recent observations that a polymorphism in the gene encoding PfATP6 is associated with in vitro resistance to artemether in field isolates of P. falciparum.

Item Type: Article
Additional Information: Copyright © 2006 Elsevier Ltd. Under a Creative Commons license CC BY 3.0
Keywords: Antimalarials, Artemisinins, Drug Resistance, Genes, Protozoan, Heme, Humans, Protozoan Proteins, Sesquiterpenes, Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, Medicine, Research & Experimental, Research & Experimental Medicine, ANTIMALARIAL-DRUG RESISTANCE, PLASMODIUM-FALCIPARUM MALARIA, MEFLOQUINE RESISTANCE, ANTIFOLATE RESISTANCE, MULTIDRUG-RESISTANCE, CHEMICAL-REACTIVITY, BIOLOGICAL-ACTIVITY, AGENT ARTEMISININ, DERIVATIVES, ARTESUNATE
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: TRENDS IN MOLECULAR MEDICINE
ISSN: 1471-4914
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Dates:
DateEvent
1 May 2006Published
Web of Science ID: WOS:000238825600005
Download EPMC Full text (HTML)
URI: http://openaccess.sgul.ac.uk/id/eprint/1023
Publisher's version: https://doi.org/10.1016/j.molmed.2006.03.005

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