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Immune system development during early childhood in tropical Latin America: Evidence for the age-dependent down regulation of the innate immune response

Teran, R; Mitre, E; Vaca, M; Erazo, S; Oviedo, G; Hübner, MP; Chico, ME; Mattapallil, JJ; Bickle, Q; Rodrigues, LC; et al. Teran, R; Mitre, E; Vaca, M; Erazo, S; Oviedo, G; Hübner, MP; Chico, ME; Mattapallil, JJ; Bickle, Q; Rodrigues, LC; Cooper, PJ (2011) Immune system development during early childhood in tropical Latin America: Evidence for the age-dependent down regulation of the innate immune response. CLINICAL IMMUNOLOGY, 138 (3). 299 - 310. ISSN 1521-6616 https://doi.org/10.1016/j.clim.2010.12.011
SGUL Authors: Cooper, Philip John

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Abstract

The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5 years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6–9 months, 22–26 months, and 48–60 months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4+ and CD8+ T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3+ T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.

Item Type: Article
Additional Information: © 2010 Elsevier Inc. Under a Creative Commons license(CC BY 3.0).
Keywords: Adaptive Immunity, Age Factors, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Child Development, Child, Preschool, Cross-Sectional Studies, Down-Regulation, Ecuador, Female, Humans, Immune System, Immunity, Innate, Infant, Interleukin-10, Lymphocyte Count, Male, Toll-Like Receptors, Science & Technology, Life Sciences & Biomedicine, Immunology, Innate immunity, Adaptive immunity, Childhood, Tropics, T-CELLS, CYTOKINE RESPONSES, HYGIENE HYPOTHESIS, ASTHMA, DIFFERENTIATION, MODULATION, MATURATION, INFECTION, DISEASE, HEALTH
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: CLINICAL IMMUNOLOGY
ISSN: 1521-6616
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Dates:
DateEvent
1 March 2011Published
Web of Science ID: WOS:000287683300008
Download EPMC Full text (HTML)
URI: http://openaccess.sgul.ac.uk/id/eprint/102232
Publisher's version: https://doi.org/10.1016/j.clim.2010.12.011

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