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Value of black blood T2*cardiovascular magnetic resonance.

Smith, GC; Carpenter, JP; He, T; Alam, MH; Firmin, DN; Pennell, DJ (2011) Value of black blood T2*cardiovascular magnetic resonance. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 13. pp. 1-6. ISSN 1097-6647
SGUL Authors: He, Taigang

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Purpose To assess whether black blood T2* cardiovascular magnetic resonance is superior to conventional white blood imaging of cardiac iron in patients with thalassaemia major (TM). Materials and methods We performed both conventional white blood and black blood T2* CMR sequences in 100 TM patients to determine intra and inter-observer variability and presence of artefacts. In 23 patients, 2 separate studies of both techniques were performed to assess interstudy reproducibility. Results Cardiac T2* values ranged from 4.5 to 43.8 ms. The mean T2* values were not different between black blood and white blood acquisitions (20.5 vs 21.6 ms, p = 0.26). Compared with the conventional white blood diastolic acquisition, the coefficient of variance of the black blood CMR technique was superior for intra-observer reproducibility (1.47% vs 4.23%, p < 0.001), inter-observer reproducibility (2.54% vs 4.50%, p < 0.001) and inter-study reproducibility (4.07% vs 8.42%, p = 0.001). Assessment of artefacts showed a superior score for black blood vs white blood scans (4.57 vs 4.25; p < 0.001). Conclusions Black blood T2* CMR has superior reproducibility and reduced imaging artefacts for the assessment of cardiac iron, in comparison with the conventional white blood technique, which make it the preferred technique for clinical practice.

Item Type: Article
Additional Information: PubMed ID: 21401929. © 2011 Smith et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adolescent, Adult, Artifacts, Blood Transfusion, Child, Female, Heart Diseases, Hemosiderosis, Humans, Image Interpretation, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Observer Variation, Predictive Value of Tests, Reproducibility of Results, Young Adult, beta-Thalassemia, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, MYOCARDIAL IRON OVERLOAD, THALASSEMIA MAJOR, BETA-THALASSEMIA, IN-VIVO, DEFEROXAMINE, REPRODUCIBILITY, COMPLICATIONS, DEFERIPRONE, DIAGNOSIS, SURVIVAL
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
ISSN: 1097-6647
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14 March 2011Published
Web of Science ID: WOS:000288614100001
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