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Anti-platelet therapy: ADP receptor antagonists.

Wijeyeratne, YD; Heptinstall, S (2011) Anti-platelet therapy: ADP receptor antagonists. British Journal of Clinical Pharmacology, 72 (4). 647 - 657. ISSN 0306-5251 https://doi.org/10.1111/j.1365-2125.2011.03999.x
SGUL Authors: Wijeyeratne, Yanushi Dullewe

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Abstract

The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.

Item Type: Article
Additional Information: © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
Keywords: Blood Platelets, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Purinergic P2Y Receptor Antagonists, Thrombosis
Journal or Publication Title: British Journal of Clinical Pharmacology
ISSN: 0306-5251
Dates:
DateEvent
1 October 2011Published
PubMed ID: 21518389
Web of Science ID: 21518389
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URI: http://openaccess.sgul.ac.uk/id/eprint/100864
Publisher's version: https://doi.org/10.1111/j.1365-2125.2011.03999.x

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