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The mouse immune response to carrier erythrocyte entrapped antigens

Murray, AM; Pearson, IF; Fairbanks, LD; Chalmers, RA; Bain, MD; Bax, BE (2006) The mouse immune response to carrier erythrocyte entrapped antigens. VACCINE, 24 (35-36). 6129 - 6139. ISSN 0264-410X https://doi.org/10.1016/j.vaccine.2006.05.013
SGUL Authors: Bax, Bridget Elizabeth

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Abstract

This study investigated the potential of a single administration of carrier erythrocyte entrapped antigen to elicit humoral responses in the Balb/c mouse. Humoral responses to primary immunizations of erythrocyte encapsulated antigens were compared with those obtained with adjuvanted antigen administered via the subcutaneous route. Ig isotype responses to primary immunizations of erythrocyte entrapped antigen and subcutaneous antigen were compared to responses observed in mice that subsequently received booster immunizations with un-entrapped antigen. This study demonstrates that a single administration of antigen-loaded carrier erythrocytes is able to elicit humoral immune responses comparable or superior to those obtained via the adjuvanted subcutaneous vaccination route. The IgG isotype profiles demonstrate that the erythrocyte entrapment of antigens is another mechanism by which the Th responses to antigens maybe modulated.

Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Vaccine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Vaccine [24, 35-36, (28 Aug 2006)] 10.1016/j.vaccine.2006.05.013
Keywords: Animals, Antibody Formation, Antigens, Erythrocytes, Female, Immunization, Immunoglobulin G, Mice, Mice, Inbred BALB C, Science & Technology, Life Sciences & Biomedicine, Immunology, Medicine, Research & Experimental, Research & Experimental Medicine, antigen delivery system, carrier erythrocytes, antigen presenting cells, RED-BLOOD-CELLS, KEYHOLE LIMPET HEMOCYANIN, ADENOSINE-DEAMINASE, CROSS-PRESENTATION, DENDRITIC CELLS, T-CELLS, IN-VIVO, NEUTRALIZING ANTIBODIES, MEDIATED DELIVERY, ENTRAPMENT, antigen delivery system, carrier erythrocytes, antigen presenting cells
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: VACCINE
ISSN: 0264-410X
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Dates:
DateEvent
28 August 2006Published
Web of Science ID: WOS:000240398000011
URI: http://openaccess.sgul.ac.uk/id/eprint/100457
Publisher's version: https://doi.org/10.1016/j.vaccine.2006.05.013

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